Whether you’re trying to outsmart your co-workers in the office survivor pool, placing a bet with a sportsbook, or looking for an edge creating your DFS lineups, our weekly guide to gambling on the NFL has everything you need to win big during Week 2.
All the essentials are in one place, from updated odds and spreads, our experts’ picks (straight up and against the spread), and a game-by-game guide to trends and injury reports every bettor should know before placing their wager. There are tips for making your survivor and pick ’em pool picks this week. And if daily games are more your speed, you’ll find advice on building the ideal lineups for the most popular games on DraftKings, FanDuel and Yahoo.
Looking for betting information on this week’s college football games? You can also find our picks (straight up, against the spread), Week 3 confidence index and more here.
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MORE: Get the latest NFL odds at Sportsbook Review
NFL odds, spreads for Week 2 games
Here are the latest odds and point spreads for every Week 2 NFL game, via Sportsbook Review (last updated: Sept. 15).
| Time (ET) | Matchup (TV) | Odds | Total |
| Thursday, Sept. 12 | |||
| 8:20 p.m. | Tampa Bay Buccaneers at Carolina Panthers (NFLN) | CAR -7 | 50.5 |
| Sunday, Sept. 15 | |||
| 1 p.m. | Indianapolis Colts at Tennessee Titans (CBS) | TEN -5.5 | 44 |
| 1 p.m. | Los Angeles Chargers at Detroit Lions (CBS) | LAC -2.5 | 47 |
| 1 p.m. | Buffalo Bills at New York Giants (CBS) | BUF -2.5 | 42.5 |
| 1 p.m. | Arizona Cardinals at Baltimore Ravens (Fox) | BAL -14 | 41.5 |
| 1 p.m. | New England Patriots at Miami Dolphins (CBS) | NE -15.5 | 47 |
| 1 p.m. | Dallas Cowboys at Washington Redskins (Fox) | DAL -7 | 44 |
| 1 p.m. | Jacksonville Jaguars at Houston Texans (CBS) | HOU -10 | 43.5 |
| 1 p.m. | Seattle Seahawks at Pittsburgh Steelers (Fox) | PIT -4.5 | 46.5 |
| 1 p.m. | San Francisco 49ers at Cincinnati Bengals (Fox) | Pick ’em | 45 |
| 1 p.m. | Minnesota Vikings at Green Bay Packers (Fox) | GB -2.5 | 46 |
| 4:05 p.m. | Kansas City Chiefs at Oakland Raiders (CBS) | KC -10 | 53.5 |
| 4:25 p.m. | New Orleans Saints at Los Angeles Rams (Fox) | LAR -2.5 | 53.5 |
| 4:25 p.m. | Chicago Bears at Denver Broncos (Fox) | Pick ’em | 40.5 |
| 8:20 p.m. | Philadelphia Eagles at Atlanta Falcons (NBC) | Pick ’em | 51 |
| Monday, Sept. 16 | |||
| 8:15 p.m. | Cleveland Browns at New York Jets (ESPN) | Pick ’em | 45 |
Expert NFL picks, predictions for Week 2
Straight up: In our picks and predictions for Week 2 of the 2019 NFL season, Minnesota takes control of its division with a win in Green Bay and Pittsburgh rebounds with a win against Seattle.
Against the spread: In our NFL picks against the spread for Week 2, Los Angeles gets the best of New Orleans again, this time at home. Speaking of repeat winners, Philadelphia beats Atlanta for the second consecutive year.
Weak betting lines to exploit: Each week, there are a few games where the betting lines seem a bit soft. Sportsbook Review isolates those contests so you can grab the cash this weekend.
Underdog picks with good odds: The Dolphins and Redskins are overlooked by bettors in their Week 2 matchups, making them smart picks heading into the weekend.
Best two-team parlay pick: Sportsbook Review’s experts pick two games to pair in your Week 2 NFL parlay bets based on their moneylines entering the weekend.
Week 2 touchdown projections: Sportsbook Review looks at the anytime scorer odds — one short odds (minus money), one middling (+150 or so) and one longshot from the NFL’s Week 2 games.
FANTASY FOOTBALL RANKINGS:
Quarterback | Running back | Wide receiver | Tight end | D/ST | Kicker
Tips, advice for pick ’em, survivor pools
Week 2 survivor pool tips: Is it worth picking any team other than the Patriots or Ravens in your survivor pool this week? The number-crunching experts at TeamRankings weigh in on potential Week 2 contrarian picks for eliminator football pools.
Week 2 picks for confidence, pick ’em pools: Getting the biggest edge in your NFL pick ’em pool in Week 2 requires knowing not only every team’s win odds (i.e. how risky of a pick it is), but also its pick popularity in your pool (i.e. how much you’ll gain in the standings if you pick that team and it wins).
NFL Week 2 betting guides
Game-by-game betting guide: Sportsbook Review has everything you need to know before betting on the NFL’s Week 2 games contained within this handy cheat sheet, including updated odds, point spreads, injury reports and more for every game.
Thursday Night Football: Desperation will be a factor for both the Buccaneers and the Panthers as the NFC South rivals kick off Week 2 in the NFL. Here’s everything to know before betting on the “Thursday Night Football” game, including updated odds, trends and our expert’s prediction.
Sunday Night Football: The offenses for the Eagles and Falcons are too loaded in the passing game to not think this will be a high-scoring affair. Here’s everything to know about the NFL’s Week 2 “Sunday Night Football” game, including updated odds, trends and our expert’s prediction.
Monday Night Football: The Browns and Jets were two of the most hyped teams in the NFL before they both suffered deflating home losses to open the 2019 season. Here’s everything to know about the NFL’s Week 2 “Monday Night Football” game, including updated odds, trends and our expert’s prediction.
NFL DFS picks & strategy for Week 2 games
FanDuel
Core plays for cash games: Your Week 2 FanDuel cash game lineup should start off with some core plays, including Matt Breida at running back and everyone’s favorite sleeper, Darren Waller, at tight end.
Lineup advice for GPP tournaments: Bennett Bedford is here to help with your Week 2 FanDuel picks. See his four core plays for NFL DFS tournaments, including Josh Allen as a value QB and Stefon Diggs as a WR sleeper, and an example of how to fill in the rest of your lineup.
DraftKings
Best lineup stacks: Your Week 2 NFL DFS stacks could include Josh Allen and John Brown in cash games and focus on Ben Roethlisberger and JuJu Smith-Schuster in GPP tournaments.
Lineup advice for cash games: Our Week 2 DraftKings picks for NFL DFS cash games take advantage of slow-to-adjust pricing.
Lineup advice for GPP tournaments: See our DraftKings lineup picks and pick up more NFL DFS tournament tips for Week 2.
Buccaneers vs. Panthers DFS advice: If you’re putting together a DraftKings Showdown lineup, we’ve got the picks, advice and sleepers to help in your tournaments.
Yahoo
Lineup advice for cash games: We’re playing some home-road splits and exploiting bad defenses with our Week 2 Yahoo cash lineup picks.
Lineup advice for GPP tournaments: Saquon Barkley and DeAndre Hopkins headline our Yahoo DFS GPP lineup for Week 2, but players like Rex Burkhead and Ryan Switzer could make all the extra difference for winning daily fantasy football tournament picks.