The First One-Pot Synthesis of l-7-Iodotryptophan from 7-Iodoindole and Serine, and an Improved Synthesis of Other l-7-Halotryptophans
DRM Smith, T Willemse, DS Gkotsi, W Schepens, BUW Maes,S Ballet , RJM Goss, Org. Lett., 2014, 16, 2622–2625.
A simple and scalable one-pot biotransformation enables direct access to l-halotryptophans, including l-7-iodotryptophan, from the corresponding haloindoles. The biotransformation utilizes an easy to prepare bacterial cell lysate that may be stored as the lyophilizate for several months and utilized as a catalyst as and when required.
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Keyword: Hyperbaric Chamber 1.5 ATA