France head coach Fabien Galthie has kept faith with the team which narrowly beat Australia in their Autumn Nations Series opener.
With a game under their belts, Romain Ntamack and Cyril Baille are retained after only recently returning from injury.
Talented half-back partnership
Ntamack partners with Antoine Dupont at half-back, while Jonathan Danty and Gael Fickou combine at centre.
Damian Penaud, who was the hero against the Wallabies last week, will hope to continue his form alongside Thomas Ramos and Yoram Moefana in the back three.
Baille, Julien Marchand and Uini Atonio once again make up a powerful front-row but they will be severely tested by a strong Springbok scrum this weekend.
Thibaud Flament and Cameron Woki form an athletic second-row partnership, with Gregory Alldritt, Charles Ollivon and Anthony Jelonch having a nice balance in the loose trio.
Two possible debutants
The only changes for France come on the bench with prop Reda Wardi set for his first cap.
Elsewhere, Kilian Geraci is out injured which means Bastien Chalureau is another potential debutant.
Galthie’s squad is completed by Peato Mauvaka, Sipili Falatea, Romain Taofifenua, Sekou Macalou, Maxime Lucu and Matthieu Jalibert.
France: 15 Thomas Ramos, 14 Damian Penaud, 13 Gael Fickou, 12 Jonathan Danty, 11 Yoram Moefana, 10 Romain Ntamack, 9 Antoine Dupont (c), 8 Gregory Alldritt, 7 Charles Ollivon, 6 Anthony Jelonch, 5 Thibaud Flament, 4 Cameron Woki, 3 Uini Atonio, 2 Julien Marchand, 1 Cyril Baille
Replacements: 16 Peato Mauvaka, 17 Reda Wardi, 18 Sipili Falatea, 19 Romain Taofifenua, 20 Bastien Chalureau, 21 Sekou Macalou, 22 Maxime Lucu, 23 Matthieu Jalibert
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Date: Saturday, November 12
Venue: Stade Velodrome, Marseille
Kick-off: 21:00 local (20:00 GMT)
Referee: Wayne Barnes (England)
Assistant Referees: Karl Dickson (England), Christophe Ridley (England)
TMO: Brian MacNeice (Ireland)