Epimerization in peptide thioester condensation.
Epimerization in peptide thioester condensation. K. Teruya, T. Tanaka, T. Kawakami, K. Akaji, S. Aimoto, J Pept Sci. 2012 Sep 13. doi: 10.1002/psc.2452. [Epub ahead of print] Peptide segment couplings are now widely utilized in protein chemical synthesis. One of the key structures for the strategy is the peptide thioester. Peptide thioester condensation, in which a C-terminal peptide thioester is selectively activated by silver ions then condensed with an amino component, is a powerful tool.…